Slit-Robo signaling
نویسندگان
چکیده
منابع مشابه
Slit-Robo signaling.
Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously and Slit-Robo signaling has been linked to roles in neurogenesis, angiogenesis and cancer progression among other processes. Likewise, ...
متن کاملSlit/Robo Signaling: Inhibition of Directional Leukocyte Migration
Localized inflammation and the associated influx of leukocytes is a hallmark of the pathogenesis of many diseases. The ability to target the recruitment of leukocytes holds vast therapeutic potential in inflammatory diseases where there is excessive cell recruitment due to an overactive immune response, or the improper resolution of the initial response resulting in chronic leukocyte infiltration.
متن کاملStructural insight into Slit-Robo signalling.
Drosophila Slit and its vertebrate orthologues Slit1-Slit3 are secreted glycoproteins that play important roles in the development of the nervous system and other organs. Human Slits are also involved in a number of pathological situations, such as cancer and inflammation. Slits exert their effects by activating receptors of the Robo (Roundabout) family, which resemble cell adhesion molecules i...
متن کاملStructural Basis of Robo Proline-rich Motif Recognition by the Srgap1 Sh3 Domain in the Slit-robo Signaling Pathway
STRUCTURAL BASIS OF ROBO PROLINE-RICH MOTIF RECOGNITION BY THE SRGAP1 SH3 DOMAIN IN THE SLIT-ROBO SIGNALING PATHWAY Xiaofeng Li, Yushu Chen, Yiwei Liu, Jia Gao, Feng Gao, Mark Bartlam, Jane Y. Wu & Zihe Rao 1 “Tsinghua-IBP Joint Research Group for Structural Biology”, Tsinghua University, Beijing 100084, China. 2 National Laboratory of Biomacromolecules, Institute of Biophysics (IBP), Chinese A...
متن کاملInduction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity.
Slit is a secreted protein known to function through the Roundabout (Robo) receptor as a chemorepellent in axon guidance and neuronal migration, and as an inhibitor in leukocyte chemotaxis. Here we show Slit2 expression in a large number of solid tumors and Robo1 expression in vascular endothelial cells. Recombinant Slit2 protein attracted endothelial cells and promoted tube formation in a Robo...
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ژورنال
عنوان ژورنال: Development
سال: 2016
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.132829